(1) (2) (3), where AUC is the area under the drug concentration-time steady state, F is the bioavailability of drugs, the CL is total clearance of the drug, the CSS (t) is the concentration of drug in purchase soma 200mg Richmond a constant state over time (t), k is the absorption rate constant, V is the volume of distribution, k is the elimination constant, τ is the interval dosage, and Support Services, the maximum time to maximum concentration. Logistic regression was performed to examine the association between pharmacokinetic parameters (AUC, Cmax, Cmin y) and toxicity (cycle 1 rash and diarrhea). In the analysis of these and all others, two sets of comparisons were made, a grade 0 toxicity dichotomous as compared to grade 1 or worse (ie, no toxicity v) and classification of toxicity of second-degree 0 purchase soma 200mg Richmond or 1 versus grade 2 purchase soma 200mg Richmond or worse. analysis of variance t tests were performed to assess the association between polymorphisms and various pharmacokinetic parameters. As the modes of transmission is unknown or is purchase soma 200mg Richmond not clearly identifiable in the data represented, four types of analysis are generally carried out an analysis of variance with two degrees of freedom (df) to test the null hypothesis of equal levels average pharmacokinetic parameters in the three genotypes, purchase soma 200mg Richmond followed by t tests and linear regression analysis for the evaluation of dominant models, recessive and additive.
For example, the hypothetical variation purchase soma 200mg Richmond of AB, we have the genotypes purchase soma 200mg Richmond A / A / B and B / B. In the additive model, the independent variable would be coded as follows: A / A = 0, A / B = 1, B / B = 2. The dominant model purchase soma 200mg Richmond is coded as follows: A / A = 0, A / B purchase soma 200mg Richmond = 1, B / B = 1. The recessive model would purchase soma 200mg Richmond be coded as follows: A / A = 0, A / B = 0, B / B = 1 Fisher's exact test were used to analyze the association between genetic polymorphisms and toxicity.
For the EGFR intron 1 (CA) n polymorphism, examined the association purchase soma 200mg Richmond between the number of repetitions of CA and toxicity as follows. The number of repetitions of a given allele AC ranges from 14 to 22, with an allele with 25 additional repetitions. Forward the hypothesis that patients with ≤ 16 repeat allele have a phenotype distinct from those with more repetitions. Therefore, patients classified as "s / s" if the number of repetitions was ≤ 16 in both alleles, "L / L" if the number of repeats was 16 in both alleles, and "S / L" if the number of repeats in one alleleis ≤ 16 and the number of the other allele is 16. However, we also consider other thresholds, r, 17, 18, 19 and 20. The data were analyzed using Fisher's exact test and the Armitage test for linear purchase soma 200mg Richmond trend in the values of p between 0.05 and 0.10 proportions.5 were slightly more suggestive of an association (in bold) while P 0, 05 was considered statistically significant () in bold italics.
P values significant or only marginally significant in the tables, with other results reported as not significant ("NS").
However, note that for the analysis of CA repeat, because five different cutoff points were considered, the Bonferroni correction would require P 0.05 / 5 = 0.01 for statistical significance.
